Abnormal mitosis in reactive astrocytes
نویسندگان
چکیده
منابع مشابه
Diversity in Reactive Astrocytes
Normal astrocytes in the adult undergo hypertrophy and proliferation and transform into reactive astrocytes following many types of central nervous system (CNS) injury (1–5). This process is termed astrogliosis and may result in the formation of a glial scar. Morphological studies on astrogliosis by neuroanatomists and pathologists at the beginning of this century focused on the most florid exa...
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Cellular defects that impair the fidelity of mitosis promote chromosome missegregation and aneuploidy. Increasing evidence reveals that errors in mitosis can also promote the direct and indirect acquisition of DNA damage and chromosome breaks. Consequently, deregulated cell division can devastate the integrity of the normal genome and unleash a variety of oncogenic stimuli that may promote tran...
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Correspondence to Neil J. Ganem: [email protected] Introduction Progression from a nontransformed normal cell to a malignant cancer cell requires multiple genetic changes that hyperactivate oncogenes while restraining tumor suppressors (Hanahan and Weinberg, 2011). This occurs via two distinct, but not mutually exclusive, mechanisms: the acquisition of genetic mutations, and gene copy...
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ژورنال
عنوان ژورنال: Acta Neuropathologica Communications
سال: 2020
ISSN: 2051-5960
DOI: 10.1186/s40478-020-00919-4